Reflectance confocal microscopy (RCM) showed numbers of bright tumor islands with peripheral palisading, cleft-like dark spaces, and dilated canalicular vessels in the dermis (Figure 1C). As noninvasive and convenient imaging technologies, dermoscopy, RCM and HFUS are sensitive and specific tools for diagnosing BCC and can provide multimodal information for the management. Dear Editor, A 59-year-old female presented with a 5-year history of a solitary skin-colored nodule on the upper lip (Figure 1A). [Extracted from the article]