Singlecrystal structures of blockbuster antihypertensive drug Valsartanare revealedthe first time in this report. Two new highly crystalline forms, namedform E and an ethanol solvate form F, were discovered and fully characterizedby PXRD, Raman, IR, TG, DSC, and DVS. Conformational flexibility andsingle crystal structures are discussed in detail. Physicochemicalproperties, such as hygroscopicity, chemical stability, crystallinity,and dissolution behaviors, are compared with the marketed solid-stateform (amorphous state). The results show that the newly discoveredhighly crystalline form E presents a remarkably different dissolutionbehavior and superior chemical stability. [ABSTRACT FROM AUTHOR]