Palladium-Catalyzed Asymmetric Cycloaddition/Cope Rearrangement Relay: Synthesis of Chiral Endocyclic Allenes.
- Resource Type
- Article
- Authors
- Shi, Bin; Xiao, Wen-Jing; Lu, Liang-Qiu
- Source
- Synlett. Oct2023, Vol. 34 Issue 16, p1845-1851. 7p.
- Subject
- *ALLENE
*RING formation (Chemistry)
*CLAISEN rearrangement
*ALLYLIC alkylation
*SERVER farms (Computer network management)
*REARRANGEMENTS (Chemistry)
- Language
- ISSN
- 0936-5214
Keywords: chiral allene; medium-sized ring; cycloaddition; Cope rearrangement; asymmetric catalysis EN chiral allene medium-sized ring cycloaddition Cope rearrangement asymmetric catalysis 1845 1851 7 09/15/23 20231004 NES 231004 Graph 1 Introduction Allene is a unique functional group with a three-carbon structure consisting of two I sp i SP 2 sp -hybridized terminal carbons and one I sp i -hybridized inner carbon (Scheme 1a). Since the correct structure and axial chirality of allenes was first predicted by the pioneer van't Hoff in 1875, [2] allenes have attracted continuous research interest from synthetic chemists for over a century, driven by the curiosity of their unique structure. [24] Another method to synthesize the 1,3-endocyclic allenes is the cyclization of skillfully designed acyclic allenes; but this is not applicable to the preparation of cyclic allenes with smaller rings. [Extracted from the article]