Uncommon reaction in 4-formyl phenols -- substitution of the formyl group.
- Resource Type
- Article
- Authors
- Lopušanskaja, Eleana; Paju, Anne; Lopp, Margus
- Source
- Proceedings of the Estonian Academy of Sciences. 2024, Vol. 73 Issue 1, p1-5. 5p.
- Subject
- *PERMUTATION groups
*PHENOLS
*PHENOL
*HALOALKANES
*BENZENE
- Language
- ISSN
- 1736-6046
4-formyl phenols with electron donating groups in ortho-position react with active alkyl halides in three directions: Williamson reaction up to 48%, aromatic substitution of the formyl group up to 36%, and addition to the ortho-position with dearomatization of the ring up to 10%. The ratio of the products depends on the substituents in the benzene ring and the used alkali and additives. [ABSTRACT FROM AUTHOR]