The full hydraulic braking systems have gradually replaced the traditional mechanically actuated brake systems due to their increased performance, reliability, and safety. Besides their excellent characteristics, the functional performance of individual components, the correlation of their performance parameters, and energy consumption are not fully explored. In this paper, An Advanced Modeling Environment for performing Simulation of engineering systems (AMESim) simulation model of a fully hydraulic braking system is developed and validated, and the sensitivity of different parameters to the system performance is predicted. The multi-factor comprehensive optimization analysis was carried out from the system level for the first time. The brake energy consumption and interaction time are evaluated through a Genetic Algorithm (GA) considering a multi-factor coupling condition. The optimization results revealed that the outlet pressure and braking pump power are reduced by 35.6%, the energy consumption is reduced by 32.8%, and the braking times are increased by 10%. [ABSTRACT FROM AUTHOR]