Metabolic Erosion Primarily Through Mutation Accumulation, and Not Tradeoffs, Drives Limited Evolution of Substrate Specificity in Escherichia coli.
- Resource Type
- Article
- Authors
- Leiby, Nicholas; Marx, Christopher J.
- Source
- PLoS Biology. Feb2014, Vol. 12 Issue 2, p1-10. 10p. 1 Diagram, 3 Graphs.
- Subject
- *ESCHERICHIA coli
*NEUTRAL mutations
*GLUCOSE
*PLEIOTROPY in bacteria
*CITRATES
*CELL respiration
*CARBON
- Language
- ISSN
- 1544-9173
: During long-term evolution of Escherichia coli, nutrient specialization is primarily driven by the accumulation of neutral mutations, rather than by tradeoffs, and can also be accompanied by general catabolic improvements. [ABSTRACT FROM AUTHOR]