Staphylococcus aureus Panton-Valentine Leukocidin Targets Muscle Tissues in a Child with Myositis and Necrotizing Fasciitis.
- Resource Type
- Article
- Authors
- Lehman, Deborah; Ching Wen Tseng; Eells, Samantha; Miller, Loren G.; Xuemo Fan; Beenhouwer, David O.; Liu, George Y.
- Source
- Clinical Infectious Diseases. 1/1/2010, Vol. 50 Issue 1, p69-72. 4p.
- Subject
- *STAPHYLOCOCCUS aureus infections
*STAPHYLOCOCCUS aureus
*STREPTOCOCCAL diseases
*MYOSITIS
*METHICILLIN resistance
*EPIDEMICS
*MUSCLE diseases
*OSTEOMYELITIS diagnosis
*NECROTIZING fasciitis
*STAPHYLOCOCCAL diseases
*DIAGNOSIS
- Language
- ISSN
- 1058-4838
The incidence of myositis has been increasing since the advent of the epidemic of community-associated methicillin-resistant Staphylococcus aureus infection, and Panton-Valentine leukocidin has been implicated as a factor contributing to more-severe muscle injury. We report a case of severe myositis accompanying septic osteomyelitis and necrotizing fasciitis caused by a Panton-Valentine leukocidin--positive S. aureus strain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues. [ABSTRACT FROM AUTHOR]