Introduction: World Health Organization (WHO) defined palliative care as "an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment, and treatment of pain and other sufferings like physical, psychosocial and spiritual". Due to limited improvement of palliative care practice in Africa, numerous patients have not received formal palliative care services. But, there are very limited researches regarding palliative care in the study area and the nation at large. The objective of this study aimed to assess the quality of palliative care practice, and it's associated factors, among nurses working in South Gondar Zone Public hospitals, Northwest Ethiopia. Methods: an institution-based cross-sectional study design was carried out. A total of 402 nurses working in all South Gondar Zone public hospitals were included in the study. The data were collected by using pre-tested English version questionnaire with self-administered interviews. The data were checked for completeness, cleaned, coded, and entered into epi data version 4.2; then, exported to SPSS version 22 for analysis. Binary logistic regression was applied to analyze the outcome variable. Results: this study revealed that most of the study participants, 341 (88.11%) had poor practice towards palliative care. Moreover, this study also showed that knowledge of PC, attitude towards PC, educational level, and years of work experience were statistically significant with nurses' quality of palliative care practice. Conclusion: this study indicated that most of the nurses working in South Gondar zone public hospitals have poor quality of palliative care practice. Therefore, all the concerned bodies should work together to enhance nurses' quality of palliative care practice by giving sustainable training and involving palliative care philosophy in nursing education, in order to expand the limited service in the area and the nation at large. [ABSTRACT FROM AUTHOR]