Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia.
- Resource Type
- Article
- Authors
- Leclerc, François; Dubois, Marie-France; Aris, Aziz
- Source
- Hypertension in Pregnancy. Aug2014, Vol. 33 Issue 3, p341-348. 8p.
- Subject
- *BISPHENOL A
*PREECLAMPSIA
*PREGNANCY complications
*COHORT analysis
*GAS chromatography/Mass spectrometry (GC-MS)
*CORD blood
*PATIENTS
- Language
- ISSN
- 1064-1955
Objectives: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. Methods: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. Results: BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. Conclusions: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta. [ABSTRACT FROM AUTHOR]