Vitiligo is an acquired depigmentary disease characterized by loss of functional melanocytes.1 Most stable vitiligo patients do not seem to have repigmentation due to a decreased number of melanocyte stem and mature cells within the skin; thus, surgical melanocyte replacement may be an option for refractory cases.2,3 Autologous hair transplantation through harvesting follicular melanocyte stem cell reservoirs has also been shown to have an effective response.2 It is well understood that HT is a mechanism of introducing pigmentary cells into the melanocyte's deficient regions and, in cases of vitiligo, a functional monotherapy for repigmentation.3 We prospectively compare hair follicular (HF) transplantation treatment alone versus PRP and HF transplantation in six patients, including three males and three females diagnosed with Fitzpatrick Skin Type IV, stable (no exacerbation and new lesions) and refractory (no improvement in spite of common treatments) vitiligo in more than past 12 months, and aged older than 18 years were enrolled in the study. The left and right lesions were randomly divided into two groups: group A was treated with HT plus PRP, and group B was treated with HT alone. Patients signed the informed consent and were aware of the treatment methods and adverse effects. [Extracted from the article]