Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia.
- Resource Type
- Article
- Authors
- Stimpson, Madeleine L.; Wolf, Julia; Charbit, Bruno; Williams, Emily L.; Lait, Philippa J. P.; Schewitz‐Bowers, Lauren P.; Lee, Richard W. J.; Bradbury, Charlotte A.
- Source
- British Journal of Haematology. Feb2024, Vol. 204 Issue 2, p644-648. 5p.
- Subject
- *REGULATORY B cells
*IDIOPATHIC thrombocytopenic purpura
*IMMUNOSUPPRESSION
*MYCOPHENOLIC acid
- Language
- ISSN
- 0007-1048
Summary: Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood were similar to healthy controls. In contrast, Breg numbers were significantly reduced in ITP patients treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). We also demonstrate that glucocorticoid treatment impairs Breg interleukin‐10 production via an indirect T‐cell‐mediated mechanism. [ABSTRACT FROM AUTHOR]