Highly enantioselective desymmetrization of meso- and prochiral cyclic ketones via organocatalytic Michael reaction
- Resource Type
- Article
- Authors
- Chen, Jia-Rong; Lai, Yuan-Yuan; Lu, Hai-Hua; Wang, Xu-Fan; Xiao, Wen-Jing
- Source
- Tetrahedron. Nov2009, Vol. 65 Issue 45, p9238-9243. 6p.
- Subject
- *KETONES
*CHIRALITY
*CATALYSTS
*CHEMICAL reactions
*ASYMMETRY (Chemistry)
*NITROALKENES
- Language
- ISSN
- 0040-4020
Abstract: An efficient and novel organocatalyst has been developed for the asymmetric desymmetrization of meso- and prochiral ketones by direct Michael addition to nitroolefins. This strategy can afford the desymmetrization products with excellent diastereo- (up to >99:1) and enantioselectivity (up to 96%) in great yields (up to 95%). [Copyright &y& Elsevier]