LRRK2 mediates tubulation and vesicle sorting from lysosomes.
- Resource Type
- Article
- Authors
- Bonet-Ponce, Luis; Beilina, Alexandra; Williamson, Chad D.; Lindberg, Eric; Kluss, Jillian H.; Saez-Atienzar, Sara; Landeck, Natalie; Kumaran, Ravindran; Mamais, Adamantios; Bleck, Christopher K. E.; Yan Li; Cookson, Mark R.
- Source
- Science Advances. 11/11/2020, Vol. 6 Issue 46, p1-15. 15p.
- Subject
- *LYSOSOMES
*DARDARIN
*LYSIS
*MITOGEN-activated protein kinase kinase
*GUANINE nucleotide exchange factors
*DOXYCYCLINE
*GRANZYMES
- Language
- ISSN
- 2375-2548
The article discusses that how Leucine-rich repeat kinase 2 (LRRK2) mediates tubulation and vesicle sorting from lysosomes. It mentions that genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson's disease. It discusses that biological functions of LRRK2 and recruited to lysosomes after exposure of cells to the lysosome membrane–rupturing agent LLOME.