This article explores the impact of bacterial pathogens on human health and global food security. It emphasizes the high number of deaths caused by bacterial pathogens and the economic losses due to plant pathogens. The excessive use of antibiotics and chemical pesticides has led to the emergence of antibiotic-resistant strains, highlighting the need for alternative antimicrobial strategies. The article focuses on chemotaxis, a process that allows bacteria to move in compound gradients, and its role as a virulence determinant for various bacterial pathogens. It discusses the potential of targeting bacterial motility and chemotaxis as a strategy to combat pathogens, providing examples of studies that have interfered with chemotaxis and motility to reduce bacterial virulence. The article presents various compounds that inhibit motility by interfering with Na+ and H+ gradients, reducing the expression of genes and proteins involved in chemotaxis and flagellar synthesis/functioning, and inhibiting biofilm formation. It acknowledges both the advantages and disadvantages of targeting motility and chemotaxis, highlighting the complexity of the chemotactic mechanism and the conservation of core proteins across bacteria. The article concludes that further research is needed to explore these targets and develop effective therapeutic approaches. [Extracted from the article]