Molecular Motors and Apical CFTR Traffic in Epithelia.
- Resource Type
- Article
- Authors
- Kravtsov, Dmitri V.; Ameen, Nadia A.
- Source
- International Journal of Molecular Sciences. May2013, Vol. 14 Issue 5, p9628-9642. 15p. 1 Color Photograph, 2 Charts.
- Subject
- *CYSTIC fibrosis transmembrane conductance regulator
*MYOSIN
*MICROTUBULES
*ION channels
*GENETIC mutation
- Language
- ISSN
- 1661-6596
Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement of protein motors in CFTR traffic is cell-type specific. Understanding motor specificity provides insight into the biology of the channel and opens opportunity for discovery of organ-specific drug targets for treating CFTR-mediated diseases. [ABSTRACT FROM AUTHOR]