Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca).
- Resource Type
- Article
- Authors
- Franchi, Alexander; Rauchegger, Teresa; Palme, Christoph; Frede, Katharina; Haas, Gertrud; Blatsios, Georgios; Kralinger, Martina; Zehetner, Claus
- Source
- Ocular Immunology & Inflammation. Jul2022, Vol. 30 Issue 5, p1234-1239. 6p.
- Subject
- *ADENOVIRUS diseases
*COVID-19 vaccines
*COVID-19
*OPTICAL coherence tomography
*INFRARED imaging
*CAPILLARY flow
- Language
- ISSN
- 0927-3948
To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca). Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN. Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters. We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria. [ABSTRACT FROM AUTHOR]