Double-Membrane Sampling System in a Mass Spectrometer for the Study of Exhaled Air.
- Resource Type
- Article
- Authors
- Kogan, V.; Antonov, A. S.; Chichagov, Yu. V.; Victorova-Leclerc, O. S.; Victorov, I. V.; Kozlenok, A. V.
- Source
- Technical Physics. Oct2018, Vol. 63 Issue 10, p1543-1551. 9p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 4 Graphs.
- Subject
- *VOLATILE organic compounds
*SAMPLE introduction (Chemistry)
*MASS spectrometry
*DETECTION limit
*BIOMARKERS
*COMPUTER simulation
- Language
- ISSN
- 1063-7842
Abstract: A double-membrane sample-introduction system is described that enables mass spectrometric determination of volatile organic compounds in air, while ensuring their detection limits are as low as a few fractions of ppb of sample composition in real time with a response delay from a few seconds to a few dozens of seconds. It includes two membrane interfaces separated by a volume, the gas pressure in which is maintained through a channel with an adjustable evacuation cross-section. The results of numerical simulation and experimental testing of the system are provided. A technique for selecting and calculating system parameters is described. The possibility of using this system for diagnosing diseases by trace amounts of biomarkers in exhaled air is discussed. [ABSTRACT FROM AUTHOR]