Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study.
- Resource Type
- Article
- Authors
- Malkoc, G; Dalgic, A; Koc, M; Kandogan, T; Korkmaz, S; Ceylan, M E; Inan, S; Olgun, L
- Source
- Journal of Laryngology & Otology. Aug2014, Vol. 128 Issue 8, p702-708. 7p.
- Subject
- *CORTICOSTEROIDS
*ANALYSIS of variance
*ANIMAL experimentation
*COCHLEAR implants
*DIAGNOSIS
*ELECTRODES
*ARTIFICIAL implants
*LONGITUDINAL method
*OTOACOUSTIC emissions
*RATS
*STATISTICS
*WOUNDS & injuries
*DATA analysis
*PRE-tests & post-tests
*DEXAMETHASONE
*DESCRIPTIVE statistics
*MANN Whitney U Test
- Language
- ISSN
- 0022-2151
Objective:This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application.Method:The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 µg/ml dexamethasone.Results:Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone.Conclusion:The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma. [ABSTRACT FROM PUBLISHER]