APOE loss of function: A genetic shield against Alzheimer's disease.
- Resource Type
- Article
- Authors
- Tate, Mason D.; Karahan, Hande; Kim, Jungsu
- Source
- Neuron. Apr2024, Vol. 112 Issue 7, p1033-1035. 3p.
- Subject
- *ALZHEIMER'S disease
*LONGEVITY
*APOLIPOPROTEIN E
*HUMAN genetics
- Language
- ISSN
- 0896-6273
In this issue of Neuron , Chemparathy et al. 1 provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD. In this issue of Neuron , Chemparathy et al. provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD. [ABSTRACT FROM AUTHOR]