Precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL study): study protocol for a phase II open-label multicenter trial.
- Resource Type
- Article
- Authors
- Backlund, Ellen; Yang, Muyi; Grozman, Vitali; Masucci, Giuseppe; Falkenius, Johan; Eriksson, Hanna; Jovanovic, Braslav; Hammarlund, Katarina; Isacsson, Ulf; Radu, Calin; Abel, Edvard; Karlsson, Kristin; Palanco Zamora, Ricardo; Wersäll, Peter; Edbäck, Ulrika; Wickström, Stina; Darai Ramqvist, Eva; Egyhazi Brage, Suzanne; Kiessling, Rolf; Viktorsson, Kristina
- Source
- Acta Oncologica. Jul2022, Vol. 61 Issue 7, p869-873. 5p. 1 Diagram, 1 Chart.
- Subject
- *RESEARCH
*IMMUNE checkpoint inhibitors
*CLINICAL trials
*MELANOMA
*INDIVIDUALIZED medicine
*METASTASIS
*TREATMENT effectiveness
*RADIOTHERAPY
*DRUG resistance in cancer cells
*LONGITUDINAL method
*EVALUATION
- Language
- ISSN
- 0284-186X
The article informs about the study protocol for a phase II open-label multicenter trial on Precision radiation of immune checkpoint therapy resistant melanoma metastases. Topics include the development of immune checkpoint inhibitors (ICI) and targeted therapies with BRAF and MEK inhibitors have vastly improved the outcome of patients; and Stereotactic body radiation therapy (SBRT) is today a recognized RT-technique in which the RT is delivered with inhomogeneous dose distribution.