Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots: A Case Report.
- Resource Type
- Article
- Authors
- Hirai, Nami; Ogata, Mika; Kido, Jun; Nakamura, Masashi; Sato, Nayu; Takamatsu, Nobue; Shimojo, Naoshi; Aoki, Yuji; Matsunaga, Kayoko; Mizukami, Tomoyuki
- Source
- Pediatric Allergy, Immunology & Pulmonology. Dec2022, Vol. 35 Issue 4, p166-169. 4p.
- Subject
- *BLOOD proteins
*CARROTS
*WESTERN immunoblotting
*EXERCISE-induced anaphylaxis
*URTICARIA
*GLOBULINS
*FOOD allergy
*WHEAT
*CARRIER proteins
*DISEASE complications
- Language
- ISSN
- 2151-321X
Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare case of FDEIA caused by eating carrots. Case Presentation: An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum carrot-specific immunoglobulin E level was 0.19 UA/mL. The prick-by-prick test for raw carrots was positive (wheal diameter: 4 mm). The patient developed urticaria after exercise provocation tests following ingestion of raw carrots. Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21–66 kDa. Conclusions: Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA. [ABSTRACT FROM AUTHOR]