This Study was carried out to indicate various efficacy of commercial disinfectant against velogenic vicerotropic Newcastle disease virus (vvNDV) in absence and presence of organic matter at different contact times. Four commercial disinfectants (Hydrosol, Oxidea, D.C, Quatovet (QACs) and Virkon-s at concentration 0.5%) were tested against selected viral isolate. The obtained result in this study revealed that all the tested disinfectants were effective at absence of organic matter. While, in the presence of organic matter, longer contact time was required to decrease the potency of Newcastle disease virus. Regular monitor program done in poultry farms to test the efficiency of disinfectant against this endemic virus. [ABSTRACT FROM AUTHOR]