Impact of Monkeypox Virus Infection on Immune Parameters in a Woman With Human Immunodeficiency Virus Receiving Clinically Effective Antiretroviral Therapy.
- Resource Type
- Article
- Authors
- Rai, M Ali; Shi, Victoria; Kennedy, Brooke D; Justement, Jesse S; Manning, Maegan R; Praiss, Lauren; Kang, Esther J; Gittens, Kathleen; Kardava, Lela; Blazkova, Jana; Moir, Susan; Chun, Tae-Wook
- Source
- Journal of Infectious Diseases. Aug2023, Vol. 228 Issue 3, p270-275. 6p.
- Subject
- *VIRUS diseases
*HIV
*MONKEYPOX
*HIV infections
*IMMUNE reconstitution inflammatory syndrome
*ANTIRETROVIRAL agents
- Language
- ISSN
- 0022-1899
We describe the immunologic and virologic impact of monkeypox (mpox) infection in a woman with human immunodeficiency virus (HIV) whose plasma HIV viremia was suppressed by clinically effective antiretroviral therapy. Extensive phenotypic analyses of B and T cells in peripheral blood and biomarkers in plasma showed significant immunologic perturbations despite the presence of mild mpox disease. Dramatic shifts were noted in the frequencies of total B cells, plasmablasts, and plasmablast immunoglobulin isotypes. Flow cytometric analyses showed a dramatic increase in the frequency of CD38+HLA-DR+ CD8+ T cells after mpox infection. Our data offer guidance for future studies involving mpox infection in affected populations. [ABSTRACT FROM AUTHOR]