NO-dependent osteoclast motility: reliance on cGMP-dependent protein kinase I and VASP.
- Resource Type
- Article
- Authors
- Yaroslavskiy, Beatrice B.; Yongjun Zhang; Kalla, Sara E.; Palacios, Veronica Garcia; Sharrow, Allison C.; Li, Yanan; Zaidi, Mone; Wu, Chuanyue; Blair, Harry C.
- Source
- Journal of Cell Science. 12/1/2005, Vol. 118 Issue 23, p5479-5487. 9p.
- Subject
- *NITRIC oxide
*OSTEOCLASTS
*BONE cells
*PROTEIN kinases
*ESTROGEN
*PHOSPHORYLATION
- Language
- ISSN
- 0021-9533
The article discusses research on nitric oxide (NO)-dependent osteoclast motility. NO has been implicated in the regulation of bone turnover due to stretch or through estrogen signals. It also stimulates osteoclast motility, and at high concentrations causes detachment and terminates resorption. The study demonstrated that NO regulates attachment through the cGMP-dependent protein kinase I via phosphorylation of the intermediate protein VASP.