This article discusses the ability of meglumine gadoterate, a gadolinium-based contrast agent used in magnetic resonance imaging, to induce immunoglobulin-independent activation of human mast cells. The study found that meglumine gadoterate was able to activate mast cells without affecting cell viability. The activation was mediated through the Mas-related G protein-coupled receptor member X2 (MRGPRX2). The findings suggest that non-IgE-mediated mechanisms may be responsible for immediate hypersensitivity reactions to gadolinium-based contrast agents. Further research is needed to understand the interactions between different contrast media and MRGPRX2. [Extracted from the article]