Snai2‐mediated upregulation of NADSYN1 promotes bladder cancer progression by interacting with PHB.
- Resource Type
- Article
- Authors
- Jiang, Li‐Juan; Guo, Song‐Bin; Zhou, Zhao‐Hui; Li, Zhi‐Yong; Zhou, Fang‐Jian; Yu, Chun‐Ping; Li, Mei; Huang, Wei‐Juan; Liu, Zhuo‐Wei; Tian, Xiao‐Peng
- Source
- Clinical & Translational Medicine. Jan2024, Vol. 14 Issue 1, p1-5. 5p.
- Subject
- *BLADDER cancer
*CANCER invasiveness
*NON-muscle invasive bladder cancer
*RNA-protein interactions
- Language
- ISSN
- 2001-1326
Bladder cancer is the 10th most prevalent cancer worldwide, with men having a lifetime risk of 1.1% and women 27%. The molecular mechanisms underlying the progression of bladder cancer from non-muscle invasive to muscle invasive are not well understood. This study used high-throughput RNA sequencing to identify differential gene expressions between the two types of bladder cancer. The researchers found that the upregulation of the PHB gene in muscle invasive bladder cancer tissues was associated with increased binding of the NADSYN1 mRNA to the PHB protein. Further experiments demonstrated that the interaction between PHB and NADSYN1 promoted bladder cancer progression. The study also identified Snai2 as a transcription factor that regulates the expression of NADSYN1, and its inhibition was associated with improved survival in bladder cancer patients. [Extracted from the article]