This article explores the coexistence of two rare disorders, cold agglutinin disease (CAD) and cryoglobulinaemia, which are often overlooked in diagnosis. The study reveals that a significant number of CAD patients also have cryoglobulinaemia, with potential complications such as critical ischaemia and gangrene. Treatment options for CAD include chemoimmunotherapy and complement inhibitors, while research is ongoing for cryoglobulinaemia treatment. The article recommends screening for cryoglobulins in CAD patients, particularly those experiencing circulatory symptoms. [Extracted from the article]