A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient.
- Resource Type
- Article
- Authors
- Mishra, Richa; Jamwal, Ashima; Gupta, Bishal; Kumar, Sudeep; Bharali, Abhijeet; Das, Parijat; Nath, Alok; Jain, Manoj; Neyaz, Zafar
- Source
- Lung India. Mar/Apr2024, Vol. 41 Issue 2, p130-134. 5p.
- Subject
- *CARDIAC tamponade
*ISONIAZID
*TUBERCULOSIS
*MYCOBACTERIUM tuberculosis
*SPINAL tuberculosis
MEDIASTINAL tumors
- Language
- ISSN
- 0970-2113
A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan revealed a heterogeneously enhancing lesion in the anterior mediastinum with multiple discrete lymph nodes in the cervical and mediastinal locations. The GeneXpert MTB/RIF assay performed on the CT-guided biopsy of the mass was negative, but the culture for Mycobacterium tuberculosis was positive at 7 weeks of incubation. There was a suboptimal radiological response after 6 months of treatment. First-line drug susceptibility testing (DST) performed by line probe assay (LPA) on the positive culture detected high-level resistance to isoniazid. The treatment was modified as per DST results to which the patient responded well. [ABSTRACT FROM AUTHOR]