Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry.
- Resource Type
- Article
- Authors
- Mikyung Kim; Likai Song; Moon, James; Sun, Zhen-Yu J.; Bershteyn, Anna; Hanson, Melissa; Cain, Derek; Goka, Selasie; Kelsoe, Garnett; Wagner, Gerhard; Irvine, Darrell; Reinherz, Ellis L.
- Source
- Journal of Biological Chemistry. 11/1/2013, Vol. 288 Issue 44, p31887-31901. 15p.
- Subject
- *IMMUNOGLOBULINS
*LIPOSOMES
*B cells
*VACCINATION
*HIV
*STEREOCHEMISTRY
- Language
- ISSN
- 0021-9258
Background: Despite analyses of broadly neutralizing anti-HIV-1 antibodies directed against the gp41 MPER segment, there exists a paucity of structural information on MPER immunogenicity. Results: Immunodominance of Trp-680 in the MPER arrayed on liposomes is modified by membrane anchoring. Conclusion: Immunogenicity is manipulatable through subtle structural modification. Significance: Learning about the structural basis of immunogenicity is critical for eliciting desired B cell antibody production through vaccination. [ABSTRACT FROM AUTHOR]