The Potential Functional Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells.
- Resource Type
- Article
- Authors
- Inkson, Colette A.; Ono, Mitsuaki; Yanming Bi; Kuznetsov, Sergei A.; Fisher, Larry W.; Young, Marian F.
- Source
- Cells Tissues Organs. 2008, Vol. 189 Issue 1-4, p153-157. 5p. 1 Color Photograph, 1 Diagram, 1 Graph.
- Subject
- *CELLS
*BONE marrow cells
*CONNECTIVE tissues
*EXTRACELLULAR matrix proteins
*OSTEOGENESIS imperfecta
- Language
- ISSN
- 1422-6405
Biglycan (BGN) and WISP-1 are 2 extracellular matrix proteins that bind to each other and colocalize in mineralizing tissue. Here we show that WISP-1 abrogates the repression of proliferation in bone marrow stromal cells induced by BGN. We also demonstrate that WISP-1 and its variant WISP-1va can alleviate the repressed osteogenic differentiation caused by the absence of BGN. These preliminary data suggest that WISP-1 and BGN may functionally interact and control each other’s activity, thus regulating the differentiation and proliferation of osteogenic cells. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]