Objective: The present study aims the comparison of standard-dose and low-dose CT for making a diagnosis of urolithiasis. Study design: A cross-sectional study Place and Duration: This study was conducted at Sandeman Provincial Hospital/ Bolan medical complex hospital Quetta from August 2021 to August 2022 Methodology: A total of 752 individuals were initially considered in the study. All the patients were suspected to have urolithiasis based on their clinical symptoms or sonographically. They all were referred for a CT scan for the confirmation of the diagnosis. The study was divided into two phases. In the first phase, all the patients underwent CT scans according to the protocol of standard dose. In the second phase, the patients underwent CT scans as per the protocols of low doses. Followed by the exclusion of a large number of patients, 136 patients were short-listed for a standard-dose CT scan. In addition to that, 22 patients were referred for a CT scan directly because of high suspicion of the presence of the stones. A total of 158 patients underwent a Non-Contrast Computerized Tomography Scan of the kidneys, ureter, and bladder (NCCT KUB). About 15 patients were later excluded from the study as there was no evidence of urolithiasis on the NCCT. Results Urolithiasis was detected in 143 participants, whereas, only 112 participants met the exclusion criteria. Hence, 112 patients were included in the present study. The setting of tube voltage at low tube potential by 15% reduced the dose of radiation to almost 31% in the participants undergoing CT scans to diagnose urolithiases, regardless of the body mass index (BMI). Conclusion: A combination of atomic exposure control and low tube potential is helpful in the achievement of the optimum diagnosis of urolithiasis. The present study strongly suggests that a low-dose CT scan is desirable for the diagnosis as well as follow-up in patients with urolithiasis. [ABSTRACT FROM AUTHOR]