Introduction: Lateral epicondylitis (L.E) is a common disease which effect people involved in manual job tasks. The dominant arm is generally affected the most. The annual incidence of this disease has been reported to be 1-5 percent in general population. It occurs in equal frequency in both male and females and is common in 35-40 years of age. The designation of lateral epicondylitis is a mismonomer since it has been proved now that it is not an inflammatory disorder rather a degenerative disorder in the tendon of common extensor origin. It mostly aff ects extensor carpi radialis brevis muscle origin which is a part of common extensor origin and occur due to cumulative microtrauma exceeding the normal tissue capacity to repair. Aim: To compare glyceryltrinitrate patch and local steroid injection in term of mean pain score reduction for treatment of lateral epicondylitis. Study design: Randomized controlled trial Place and Duration: In the Department of Orthopedic Surgery, District Headquarter Hospital (DHQ ) Teaching Hospital, Kohat and DHQ hospital Timergara for one year duration from March 2019 to March 2020. Material and Methods: In this study a total of 112 patients which was calculated with the help of EPI sample size calculator version 2 with following parameters. Power of study (1-β) = 90%, Confi dence level = 95 %, Mean of group A = 3.15 + 1.53, Mean of group B = 2.28 + 1.28 4 Sample A = 56, Sample B = 56. Consecutive non probability technique was used for sample collection. Results: In this study mean age in group-A 34 years with SD±18.79 where as mean age in group-B was 35 years with SD ± 19.62. In group-A 41(73%) patients were male, 15(27%) patients were female. Where as in group-B 42(75%) patients were male, 14(25%) patients were female. Difference in the mean pain score among two groups was as in Group A mean pain score was 4 ± 1.18. Where as in group-B mean pain score was 3±1.17. Conclusion: Our study concludes that glyceryltrinitrate patch is better than local steroid injection in terms of mean pain score reduction in the treatment of lateral epicondylitis. [ABSTRACT FROM AUTHOR]