Palladium‐Catalyzed Enantioselective [4+2] Cycloaddition of 4‐Vinylbenzodioxinones with Barbiturate‐Derived Alkenes: Con‐struction of Chiral Spirobarbiturate−Chromanes.
- Resource Type
- Article
- Authors
- Tang, Yi; Huang, Mingxia; Ding, Siyuan; Liu, Xinyao; Huyang, Xiaochun; Wang, Bo; Guo, Hongchao
- Source
- Chemistry - A European Journal. 4/25/2024, Vol. 30 Issue 24, p1-5. 5p.
- Subject
- *ALKENES
*RING formation (Chemistry)
*PALLADIUM
*CATALYSIS
- Language
- ISSN
- 0947-6539
In this paper, Pd‐catalyzed [4+2] decarboxylative cycloaddition of 4‐vinylbenzodioxinones with barbiturate‐derived alkenes has been developed, leading to various spirobarbiturate−chromane derivatives in high yields with excellent diastereo‐ and enantioselectivities. The scale‐up reaction and further derivation of the product were demonstrated. A plausible reaction mechanism was also proposed. [ABSTRACT FROM AUTHOR]