Tandem Phospha‐Michael Addition/N‐Acylation/ Intramolecular Wittig Reaction of aza‐o‐Quinone Methides: Approaches to 2,3‐Disubstituted Indoles.
- Resource Type
- Article
- Authors
- Hua, Ting‐Bi; Chao, Fei; Wang, Long; Yan, Chen‐Yang; Xiao, Cong; Yang, Qing‐Qing; Xiao, Wen‐Jing
- Source
- Advanced Synthesis & Catalysis. 7/16/2020, Vol. 362 Issue 13, p2615-2619. 5p.
- Subject
- *WITTIG reaction
*INDOLE
*INDOLE derivatives
*FUNCTIONAL groups
- Language
- ISSN
- 1615-4150
A tandem phospha‐Michael addition/N‐acylation/intramolecular Wittig reaction of in situ formed aza‐o‐QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biologically significant indole derivatives (37 examples, up to 91% yield) under mild reaction conditions. [ABSTRACT FROM AUTHOR]