Convenient Synthesis of 5-Aryl Uracils.
- Resource Type
- Article
- Authors
- Morshed, M.Monzur; Wang, Qinwei; Islam, Shahidul; Hossain, M.Mahmun
- Source
- Synthetic Communications. 2007, Vol. 37 Issue 23, p4173-4181. 9p. 5 Diagrams, 1 Chart, 1 Graph.
- Subject
- *URACIL
*HETEROCYCLIC compounds
*UREA
*RING formation (Chemistry)
*CHEMICAL reactions
- Language
- ISSN
- 0039-7911
A convenient one-step synthesis of 5-aryl uracils has been developed. The procedure involves heating ethyl 3-hydroxy-2-arylpropenate with urea at 130°C, followed by base-catalyzed cyclization. The method is simple and high yielding. [ABSTRACT FROM AUTHOR]