Material-Efficient Microfluidic Platform for Exploratory Studies of Visible-Light Photoredox Catalysis.
- Resource Type
- Article
- Authors
- Coley, Connor W.; Abolhasani, Milad; Hongkun Lin; Jensen, Klavs F.
- Source
- Angewandte Chemie International Edition. 8/7/2017, Vol. 56 Issue 33, p9847-9850. 4p.
- Subject
- *MICROFLUIDICS
*GAS-liquid interfaces
*PHOTON flux
*HYDROXYLATION
*DIMERIZATION
*THIOPHENOL
- Language
- ISSN
- 1433-7851
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas–liquid reactions at the 15 μL scale. An oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux made possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system. Reaction conditions identified through droplet screening translate directly to continuous synthesis with minor platform modifications. [ABSTRACT FROM AUTHOR]