Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1.
- Resource Type
- Article
- Authors
- Krall, Rebecca F.; Moutal, Aubin; Phillips, Matthew B.; Asraf, Hila; Johnson, Jon W.; Khanna, Rajesh; Hershfinkel, Michal; Aizenman, Elias; Tzounopoulos, Thanos
- Source
- Science Advances. 7/1/2020, Vol. 6 Issue 27, p1-11. 11p.
- Subject
- *GLYCINE receptors
*ZINC transporters
*METHYL aspartate receptors
*COCHLEAR nucleus
*SYNAPSES
*ZINC
*REACTIVE oxygen species
- Language
- ISSN
- 2375-2548
The article explores how how zinc inhibits synaptic N-methyl-D-aspartate receptor (NMDARs). It demonstrates that presynaptic release and a postsynaptic transporter organize zinc into distinct micro domains to modulate NMDAR neurotransmission. It discusses the disruption of ZnT1-GluN2A association by a cell-permeant peptide strongly reduced NMDAR inhibition by synaptic zinc in mouse dorsal cochlear nucleus synapses.