Combining our data with these prior reports, focusing on WHO grade 1 meningiomas only, Clark et al. found I TRAF7 i co-mutations in 50/68 I AKT1 i -mutant intracranial meningiomas (15 were I AKT1 i "isolated", and 3 were co-mutant for I AKT1/NF2 i ), while we observed only 1 of 15 co-mutant tumors. In contrast to I AKT1 i -mutant intracranial meningiomas, where I TRAF7 i mutations are found to co-occur very frequently [[5]], we observed only a single I AKT1 i -mutant SM case with a I TRAF7 i co-mutation. Subsequently, Sahm et al. screened 1437 tumors for I AKT1 i mutations and found 65 mutant cases, including 6 I AKT1 i -mutant cases in 57 SMs [[10]], and described a strong association between I AKT1 i SP I E17K i sp mutations and spinal tumor localization. [Extracted from the article]