The authors report the results of their study to determine whether mild in-vitro fertilization (IVF) treatment could lessen the discomfort of subjects, the incidence of multiple births, and treatment costs. Using a randomized, non-inferiority trial comparing results of mild or standard treatment on patients, they tested whether mild IVF treatment could also create the same chance of pregnancy. Findings indicated that, over the course of one year of treatment, rates of term livebirths and discomfort of patients were similar in both treatments, but mild IVF can reduce multiple pregnancies and overall costs.