Correction to: Biochemical Diagnosis of Bile Acid Diarrhea: Prospective Comparison With the 75Seleno-Taurohomocholic Acid Test.
- Resource Type
- Article
- Authors
- Borup, Christian; Hansen, Svend Høime; Munck, Lars Kristian
- Source
- American Journal of Gastroenterology (Lippincott Williams & Wilkins). Nov2022, Vol. 117 Issue 11, p1885-1886. 2p.
- Subject
- *BILE acids
*DIARRHEA
*LIQUID chromatography-mass spectrometry
- Language
- ISSN
- 0002-9270
We have discovered a calibrator issue in high-performance liquid chromatography-tandem mass spectrometry, meaning the reported values of 7-alpha-hydroxy-4-cholesten-3-one (C4) were proportionally lowered by a factor of 0.67 ([1]). Biobank samples reanalyzed for 7-alpha-hydroxy-4-cholesten-3-one (C4) comparing groups according to the 75-SeHCAT retention test <=10% defined bile acid diarrhea. The 26 patients with bile acid diarrhea defined by SeHCAT retention <=10% had a mean C4 level of 42 ng/mL (95% confidence interval 27-64) versus 13 ng/mL (10-16) in the 45 patients with miscellaneous diarrhea defined by SeHCAT retention >10% (Figure 1). [Extracted from the article]