Novel Cell-specific and Dominant Negative Anti-apoptotic Roles of p73 in Transformed Leukemia Cells.
- Resource Type
- Article
- Authors
- Freebern, Wendy J.; Smith, James L.; Chaudhry, Sohail S.; Haggerty, Cynthia M.; Gardner, Kevin
- Source
- Journal of Biological Chemistry. 1/24/2003, Vol. 278 Issue 4, p2249. 7p. 6 Black and White Photographs, 1 Diagram, 12 Graphs.
- Subject
- *P53 antioncogene
*GENES
*CELL cycle
*GENETIC transcription
- Language
- ISSN
- 0021-9258
Demonstrates that the differential regulatory roles of p53 family member p73 are highly cell-context and promoter-specific. Homology between related genes p53 and p73; Behavior of full-length p73 expressed in the transformed leukemia cell line Jurkat; Specific dominant negative transcriptional repressor of the cell cycle inhibitor gene p21; Blocker of p53-mediated apoptosis.