Direct Enantioselective Vinylogous Mannich Reaction of Ketimines with γ-Butenolide by Using Cinchona Alkaloid Amide/Zinc(II) Catalysts.
- Resource Type
- Article
- Authors
- Nakamura, Shuichi; Yamaji, Ryota; Hayashi, Masashi
- Source
- Chemistry - A European Journal. Jun2015, Vol. 21 Issue 27, p9615-9618. 4p.
- Subject
- *IMINES
*QUININE
*CINCHONA
*RUBIACEAE
*POLYMER aggregates
*CATALYMETRIC titration
*CHEMICAL inhibitors
*CINCHONA alkaloids
- Language
- ISSN
- 0947-6539
A direct enantioselective vinylogous Mannich reaction of ketimines with γ-butenolide has been developed. Good yields and enantioselectivities were observed for the reaction of various ketimines by using a cinchona alkaloid amide/Zn(OTf)2 catalyst and Et3N. Both enantiomers of the products could be obtained by using pseudoenantiomeric chiral catalysts. [ABSTRACT FROM AUTHOR]