A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.
- Resource Type
- Article
- Authors
- Breslin, Thomas; Paino, Jason; Wegner, Marie; Engels, Elette; Fiedler, Stefan; Forrester, Helen; Rennau, Hannes; Bustillo, John; Cameron, Matthew; Häusermann, Daniel; Hall, Christopher; Krause, Dieter; Hildebrandt, Guido; Lerch, Michael; Schültke, Elisabeth
- Source
- Biomimetics (2313-7673). Jun2023, Vol. 8 Issue 2, p230. 11p.
- Subject
- *IMAGING phantoms
*RADIOTHERAPY
*RADIATION dosimetry
*COMPUTED tomography
*DATA analysis
- Language
- ISSN
- 2313-7673
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells. [ABSTRACT FROM AUTHOR]