Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.
- Resource Type
- Article
- Authors
- Lorenz, Natalie; Ho, Timothy K C; McGregor, Reuben; Davies, Mark R; Williamson, Deborah A; Gurney, Jason K; Smeesters, Pierre R; Baker, Michael G; Moreland, Nicole J
- Source
- Clinical Infectious Diseases. Dec2021, Vol. 73 Issue 12, p2322-2325. 4p.
- Subject
- *STREPTOCOCCAL disease diagnosis
*RHEUMATIC fever
*IMMUNOGLOBULINS
*SERODIAGNOSIS
*PEPTIDES
- Language
- ISSN
- 1058-4838
Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis. [ABSTRACT FROM AUTHOR]