Biopsy‐based single‐cell transcriptomics reveals MAIT cells as potential targets for controlling fibrosis‐related liver inflammation due to chronic hepatitis‐B infection.
- Resource Type
- Article
- Authors
- Shao, Li; Zhao, Hong; Guo, Rongfang; Cheng, Jinlin; Lu, Xiaoyan; Fan, Xiaohui
- Source
- Clinical & Translational Medicine. Oct2022, Vol. 12 Issue 10, p1-7. 7p.
- Subject
- *LIVER histology
*HEPATITIS
*HEPATITIS B
- Language
- ISSN
- 2001-1326
(F) Developmental trajectory for differential T cell subclusters gl We further confirmed the presence of two MAIT cell populations by immunofluorescence, and annotated them as I CD3 i SP + sp I SLC4A10 i SP + sp I TNFAIP3 i SP + sp (T7) and I CD3 i SP + sp I SLC4A10 i SP + sp I TNFAIP3 i SP - sp (T6) MAIT cells (Figure 3). Inspired from the decrease of MAIT cells and increased ratio of T6 versus T7 during liver inflammation progression, MAIT cells may act as a potential target for controlling HBV-related liver inflammation in future studies. Biopsy-based single-cell transcriptomics reveals MAIT cells as potential targets for controlling fibrosis-related liver inflammation due to chronic hepatitis-B infection In conclusion, our study reported the remodelling of T cell subpopulations and the presence of two MAIT cell populations that may contribute to HBV-related liver inflammation for the first time. [Extracted from the article]