Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms.
- Resource Type
- Article
- Authors
- Erber, Ralf; Thurnher, Andreas; Katsen, Alice D.; Groth, Gesine; Kerger, Heinz; Hammes, Hans-Peter; Menger, Michael D.; Ullrich, Axel; Vajkoczy, Peter
- Source
- FASEB Journal. Feb2004, Vol. 18 Issue 2, p338-340. 3p. 1 Black and White Photograph, 1 Diagram.
- Subject
- *VASCULAR endothelial growth factors
*PLATELET-derived growth factor
*REGRESSION analysis
*TUMORS
*GROWTH factors
- Language
- ISSN
- 0892-6638
Presents a study on the effectiveness of combined inhibition of vascular endothelial growth factor (VEGF) and platelet-derived growth factor signaling to enforce tumor vessel regression. Failure of selective targeting of VEGF signaling to induce regression of tumor vessels; Protection of tumor blood vessels from enforced regression by pericytes; Induction of tumor blood vessel regression and hypoxia by targeting of endothelial cells; Involvement of endothelial cell apoptosis and detachment in regression of tumor blood vessels; Conclusions of the study.