Targeted imaging of integrins in cancer tissues using photocleavable Ru(II) polypyridine complexes as mass-tags.
- Resource Type
- Article
- Authors
- Han, Jiaying; Sun, Jing; Song, Shanshan; Beljaars, Leonie; Groothuis, Geny M. M.; Permentier, Hjalmar; Bischoff, Rainer; Halmos, Gyorgy B.; Verhoeven, Cornelia J.; Amstalden van Hove, Erika R.; Horvatovich, Peter; Casini, Angela
- Source
- Chemical Communications. 6/4/2020, Vol. 56 Issue 44, p5941-5944. 4p.
- Subject
- *MASS spectrometry
*TISSUES
*CANCER
- Language
- ISSN
- 1359-7345
Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(II) polypyridine complexes as mass-tags for imaging of integrins αvβ3 in human cancer tissues. [ABSTRACT FROM AUTHOR]