Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats.
- Resource Type
- Article
- Authors
- St. Laurent, Robyn; Helm, Samuel R.; Glenn, Melissa J.
- Source
- Neuroscience Letters. Jun2013, Vol. 544, p94-99. 6p.
- Subject
- *COCAINE abuse
*BRAIN-derived neurotrophic factor
*NEUROTROPHINS
*BIOLOGICAL extinction
*LABORATORY rats
*NEUROCHEMISTRY
- Language
- ISSN
- 0304-3940
Highlights: [•] BDNF+/− rats incompletely express brain derived neurotrophic factor. [•] Wildtype rats show a cocaine preference in a CPP apparatus. [•] BDNF+/− rats do not show a cocaine preference in a CPP apparatus. [•] Reduced BDNF limits acquisition of cocaine seeking behaviors. [•] Serum BDNF predicted cocaine-seeking behavior on extinction day 1. [ABSTRACT FROM AUTHOR]