Keywords: Crohn's disease; Perianal fistula; Seton; Fistulotomy; Quality of life; Female sexual function EN Crohn's disease Perianal fistula Seton Fistulotomy Quality of life Female sexual function 2686 2689 4 10/20/21 20211001 NES 211001 Introduction The basic principles for the treatment of perianal fistulas (PF) in Crohn's disease (CD) include control of perianal sepsis with abscess drainage and non-cutting seton placement initially, followed by definite treatment which aims fistula tract healing.[1] None of the modern surgical approaches for definite treatment has provided strong evidence of effectiveness through high quality studies.[2] Since the optimal time for seton removal is unknown, many experts support the use of loose permanent setons (PS).[3], [4] The purpose of this study was to examine the impact of PS in patients' quality of life (QoL). References 1 Spinelli A, Armuzzi A, Ciccocioppo R, Danese S, Gionchetti P, Luglio G. Management of patients with complex perianal fistulas in Crohn's disease: optimal patient flow in the Italian clinical reality. Is the Quality of Life of Patients with Fistulizing Perianal Crohn's Disease Impaired by the Presence of Chronic Loose, Non-cutting Seton?. [Extracted from the article]