Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation.
- Resource Type
- Article
- Authors
- Liu, Aiping; Long, Yin; Li, Jun; Gu, Long; Karim, Aos; Wang, Xudong; Gibson, Angela L. F.
- Source
- Journal of Nanobiotechnology. 9/20/2021, Vol. 19 Issue 1, p1-14. 14p. 2 Color Photographs, 5 Graphs.
- Subject
- Language
- ISSN
- 1477-3155
Background: Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy. Methods: We adapted a human skin xenograft model that can be used to directly examine the nanogeneratordriven ES (NG-ES) efects on human skin in vivo—an essential translational step toward clinical application of the NG-ES technique for wound healing. Results: We show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. NG-ES accelerates the infammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization. Conclusion: Our results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efcient wound healing therapy for use in human wounds. [ABSTRACT FROM AUTHOR]